Congratulations, George! You can look and feel 6 years younger.
Smarter Longevity exists to track the medical science and offer the best solutions that are deemed safest and most effective to extend your peak health and retard symptoms of aging. Areas medical science is demonstrating impact that can be available to you:
Ingestible, topical and skin treatments are now available to improve skin tone, overall texture and reduce evidence of aging. Treatments such cryotherapy, infrared sauna and other services are proving to have tangible benefits.
Metabolic health is a key lever for health span optimization. Through metabolic health interventions we can help healthy cells be more efficient in utilizing energy, and cut off fuel sources for unhealthy dysfunctional cells.
When we trigger autophagy through interventions like fasting and taking therapies like Metformin and Rapamycin, our cells undergo a process of recycling toxins and debris, just like hitting the reset button and help a damaged cell return to optimal smooth function. This has a profound effect on maintaining optimal health and staving off chronic diseases.
In aging, all roads lead to senescent cells. As we accumulate senescent cells we have less energy and are more fragile. As we age we accumulate more damaged and dysfunctional cells that are unable to carry out their original functions. Some of these cells—senescent cells—go a step further and recruit healthy cells to be dysfunctional as well. Smarter Longevity focuses on interventions that target these damaged senescent cells.
The speed and efficiency of new learning typically declines with age, as does sensory functioning affecting hearing and vision. Such changes can hamper the effectiveness with which people engage with work, families and communities. Explore options to improve cognitive performance longevity through diet, supplementation and behavior.
Core Principles of Aging
6.5 Years Younger
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Regenerative medicine for aging is a multidisciplinary one and includes tissue engineering, stem cell therapeutics, gene therapy, pharmacology, regenerative medicine, and many others.
Ultimately the goal of our field is the prevention, delay, or even reversal of age-related diseases. It aims to achieve this by making us biologically younger by directly targeting the aging processes as well as slowing down the rate at which we age.
There are nine proposed reasons we age:
Genomic instability – DNA damage that mutates cells potentially leading to cancer.
Telomere attrition – The caps on our chromosomes wear down leading to loss of tissue regeneration.
Epigenetic alterations – Changes to gene expression that harms healthy cellular function.
Loss of proteostasis – Loss of efficient protein production leading to accumulated cellular waste.
Deregulated nutrient sensing – Failure of metabolism leading to decline of energy production, cell growth, and other crucial cell functions.
Mitochondrial dysfunction – Free radicals damage our mitochondria leading to loss of energy production.
Cellular senescence – An accumulation of worn out damaged cells which lead to chronic inflammation and loss of tissue regeneration.
Stem cell exhaustion – A decline in the ability of our stem cells to replenish damaged tissues by sending replacement cells.
Altered intercellular communication – Changes to cell-to-cell communication which leads to chronic inflammation and dysfunctional cell behavior.
These aging processes cause damage to our bodies which ultimately leads to the onset of age-related diseases. Smarter Longevity seeks to prevent age-related diseases by recommending options for repairing the damage caused by these processes and by slowing down the rate at which this damage occurs.
Of course if we can find solutions to these nine processes (spoiler alert: science has!), a happy side effect of this would likely be more healthy years of life, not a bad thing in our opinion!